Formulation and Evaluation of Glimepiride Microparticles
نویسندگان
چکیده
منابع مشابه
Formulation and Evaluation of Glimepiride Oral Capsules
Glimepiride (GMP) is poorly water soluble drug, so solubility is the main constraint for its oral bioavailability. The aim of this study was to investigate the potential of cubosomes as lipid nanocarrier to improve the solubility and sustained action of Glimepiride. Glimepiride is one of the third generation sulfonylureas used for treatment of type 2 diabetes. The rationale of this study was to...
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The present study is to establish bi-layer tablets of Glimepiride and Captopril, of which Glimepiride as immediate release and Captopril as sustained release layers. Immediate release layer was prepared by direct compression method by using cross povidone as disintegrant and sustained release layer was prepared by direct compression method by using HPMC K4 as polymer. Both powder blends of imme...
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Oral mucosal delivery of drugs promotes rapid absorption and high bioavailability, with a subsequent immediate onset of pharmacological effect. However, many oral mucosal deliveries are compromised by the possibility of the patient swallowing the active substance before it has been released and absorbed locally into the systemic circulation. The aim of this research was to introduce a new glime...
متن کاملFormulation and Evaluation of In-vitro Characterization of Gastic-Mucoadhesive Microparticles/Discs Containing Metformin Hydrochloride
The present study involves preparation and evaluation of gastric-mucoadhesive microparticles with Metformin Hydrochloride as model drug for prolongation of gastric residence time. The microparticles were prepared by the emulsification solvent evaporation technique using polymers of Carbomer 934p (C) and Ethylcellulose (EC). The microparticles were prepared by emulsion solvent evaporation method...
متن کاملFormulation and Evaluation of In-vitro Characterization of Gastic-Mucoadhesive Microparticles/Discs Containing Metformin Hydrochloride
The present study involves preparation and evaluation of gastric-mucoadhesive microparticles with Metformin Hydrochloride as model drug for prolongation of gastric residence time. The microparticles were prepared by the emulsification solvent evaporation technique using polymers of Carbomer 934p (C) and Ethylcellulose (EC). The microparticles were prepared by emulsion solvent evaporation method...
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ژورنال
عنوان ژورنال: Journal of Comprehensive Pharmacy
سال: 2014
ISSN: 2349-5669
DOI: 10.37483/jcp.2014.1302